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Metropolis Reality Forums « Stem Cell Research Shows Promise for Hearing »

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Rhune
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Stem Cell Research Shows Promise for Hearing
« on: Aug 4th, 2005, 3:19pm »		 Quote Quote Modify Modify
http://www.cordblood.com/cord_blood_news/stem_cell_news/article_hearing_ stem_cells.asp
 
Stem Cell Research Shows Promise for Hearing  
The Hearing Journal
June 1, 2005
 
A research team at Indiana University School of Medicine has reported successfully transforming stem cells taken from adult bone marrow into cells with many of the characteristics of the sensory nerve cells in the inner ear. That feat, reported in the March 29 issue of the Proceedings of the National Academy of Sciences, may help hasten the time when bone marrow cells from a profoundly deaf patient can be used to allow the person to hear.  
 
The cells used in the research were marrow stromal cells, a type of stem cell from which fat, bone, and cartilage normally develops. Earlier research had shown that marrow stromal cells could be induced to transform into neuronal cells, but it was unclear if or how the cells could be further transformed into useful specialized neurons.  
 
Team leader Eri Hashino, PhD, and her colleagues cultivated mouse marrow stromal cells with chemicals that caused them to take the shape and other characteristics of neurons. Then they exposed the cells to two molecules secreted from nearby tissues of the ear during embryonic development. The two molecules, known as Sonic hedgehog and retinoic acid, together caused the marrow stromal cells to further develop into cells with many of the characteristics of auditory neurons, such as the presence of specific genes and proteins.  
 
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Rhune
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Re: Stem Cell Research Shows Promise for Hearing
« Reply #1 on: Aug 4th, 2005, 3:20pm »		 Quote Quote Modify Modify
on Aug 4th, 2005, 3:19pm, Rhune wrote:
The two molecules, known as Sonic hedgehog and retinoic acid

 
Who says computer gamers are geeky?  :devilish:
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AoM
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Re: Stem Cell Research Shows Promise for Hearing
« Reply #2 on: Aug 5th, 2005, 12:08pm »		 Quote Quote Modify Modify
haha, thats funny.  Actually, no one cares but i am going to tell you anyway why that gene was named Sonic the hedgehog
 
There are actually 3 genes in the hedgehog gene family, but no one ever remembers the other two.  But the other two are actual names of hedgehogs (these proteins were discovered in Drosophila, the fruit fly, and fly people are known for creative naming) anyway, there were apparently at the time only two names of hedgehogs, and they found a third protein with similarity to the other two, and they knew it was a member of that protein family, so they needed a name for the gene that showed its relationship to the other two.
 
Well grad students do most of the work, and back in the early nineties Sonic the hedgehog was a popular game, so when the boss man asked the student what we should call it, the student said 'Sonic Hegdehog" and it stuck.
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Boradamer
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Re: Stem Cell Research Shows Promise for Hearing
« Reply #3 on: Aug 9th, 2005, 11:57am »		 Quote Quote Modify Modify
I wonder if this would help with Tinitis? I have a mild case of it and it drives me nuts. I would love to have the constant ringing gone and be able to hear clearly again.
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